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DIABETES
TRATAMIENTO FARMACOLOGICO:
1.- ALTERAR ABSORCION INTESTINAL DE GLUCOSA:
- GOMAGUAR O GALACTOMANANO (FIBRAGUAR)
- INHIBIDORES DE LA GLUCOSIDASA INTESTINAL:
-Acarbosa (Glucobay, glumida)
-Migritol.
2.- INCREMENTAR CANTIDAD Y RAPIDEZ DE SECRECION DE INSULINA:
-SULFONILUREAS:
*DE 1ª GENERACION:
-ACETOHEXAMIDA
-TOLBUTAMIDA
- TOLAZAMIDA.
-CLORPROPAMIDA
*DE 2ª GENERACION:
-GLIQUIDONA
-GLIBENCLAMIDA
-GLICAZIDA
- GLIPIZIDA
* DE 3ª GENERACION:
-GLIMEPIRIDA(AMARIL)
-LINOGLERIDE
- MIDAGLIZOLE
3) DISMINUIR PRODUCCION HEPATICA DE GLUCOSA:
-HIDRACINAS
-PROINSULINA
- INHIBIDORES DE LA OXIDACION DE AC. GRASOS
4) AUMENTO DE LA UTILIZACION PERIFERICA DE GLUCOSA:
-BIGUANIDAS:
*BUTFORMINA
*METFORMINA.
*FENFORMINA.
-TROGLITAZONA.
- SULFONILUREAS.
- METILPALNOXIRATO.
ACCIONES EXTRAPANCREATICAS DE LAS SULFONILUREAS
1) HIGADO:
- Inhibición de la neoglucogenesis.
- Inhibicion de la trigliceridolipasa.
2)CORAZON: Posible acción ionotrópica débil.
3) RIÑON:
- Acción antidiurética (SIADH) (Clorpropamida).
- Leve acción diurética ( Glibencamida)
4) TIROIDES: Acción antitiroidea( ¿Carbutamida?)
5) SANGRE:
- Inhibición de la agregación plaquetaria ( Glicazida)
- Aumento de la fibrinolisis (Glicazida y glipizida)
EFECTOS SECUNDARIOS DE SULFONILUREAS:
SANGRE: Agranulocitosis, aplasia medular, anemia hemolítica.
PIEL: Rush, eritema nodoso, Stevens-Johnson, púrpura y fotosensibilidad.
TIROIDES: Posible acción antitiroidea.
VASOS SANGUINEOS. Flush, taquicardias y cefaleas(CAF)
RIÑON; SIADH
PULMON:Infiltración difusa.
TERATOGENESIS: Hipoglucemia neonatal ( no demostrado)
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Enviado por: | Kiko Gaspar |
Idioma: | castellano |
País: | España |